Gao D, Inuzuka H, Tan MM, Fukushima H, Locasale JW, Liu P, Wan L, Zhai B, Chin YR, Shaik S, Lyssiotis CA, Gygi SP, Toker A, Cantley LC, Asara JM, Harper JW & Wei W. (2011) mTOR Drives its Own Activation via SCFβ-TRCP-dependent Degradation of the mTOR Inhibitor DEPTOR. Molecular Cell. 44, 290–303. Abstract | PDF | Supporting Information

Highlighted in Nature Reviews Molecular Cell Biology (2011). mTOR Targets its Own Inhibitor | Article | PDF

Locasale JW, Grassian AR, Melman T, Lyssiotis CA, Mattaini KR, Bass AJ, Heffron G, Metallo CM, Muranen T, Sharfi H, Sasaki AT, Anastasiou D, Mullarky E, Vokes NI, Sasaki M, Beroukhim R, Stephanopoulos G, Ligon AH, Meyerson M, Richardson AL, Chin L, Wagner G, Asara JM, Brugge JS, Cantley LC & Vander Heiden MG. (2011) Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis. Nat. Genet. 43, 869–874. Abstract | PDF | Supporting Information

Highlighted in Nature Reviews Cancer (2011). Flexible Flux | Article | PDF
Highlighted in Nature Biotechnology (2011). Spotlight on Serine Metabolism in Cancer | Article
Highlighted in Cell Metabolism (2011). Serine Metabolism: Some Tumors Take the Road Less Traveled | Article | PDF
Highlighted in Science Business eXchange (2011). PHGDH | Article
Highlighted in Pigment Cell Melanoma Research (2011). Serine biosynthesis | Article | PDF

Sadanandam A, Futakuchi M, Lyssiotis CA, Gibb WJ & Singh RK. (2011) A Cross-Species Analysis of a Mouse Model of Breast Cancer-Specific Osteolysis and Human Bone Metastases Using Gene Expression Profiling. BMC Cancer. 11, 304-317. Abstract | Article | PDF

*Staerk J, *Lyssiotis CA, Medeiro LA, Bollong M, Foreman RK, Zhu S, Garcia M, Gao Q, Bouchez LC, Lairson LL, Charette BD, Supekova L, Janes J, Brinker A, Cho CY, Jaenisch R & Schultz PG. (2011) Pan-Src Family Kinase Inhibitors Replace Sox2 during the Direct Reprogramming of Somatic Cells. Angew. Chem. Int. Ed. 50, 5734–5736. Abstract | PDF | Supporting Information

Zhu S, Wurdak H, Wang Y, Galkin A, Tao H, Li J, Lyssiotis CA, Yan F, Tuu B, Miraglia L, Walker J, Sun F, Orth A, Harris J, Schultz PG & Wu X. (2009) A Genomic Screen Identifies TYRO3 as a MITF Regulator and Melanoma Oncogene. PNAS. 106, 17025–17030. Abstract | PDF | Supporting Information

Highlighted in Scripps News & Views (2009). Scientists Make Advance Against Melanoma | Article

Blatt NB, Boitano AE, Lyssiotis CA, Opipari AW & Glick GD. (2009) Bz-423 Superoxide Signals B Cell Apoptosis via Mcl-1, Bak, and Bax. Biochemical Pharmacology 78, 966–973. Abstract | PDF

*Lyssiotis CA, *Foreman RK, *Staerk J, Garcia M, Mathur D, Markoulaki S, Hanna J, Lairson LL, Charette BD, Bouchez L, Bollong M, Kunick C, Brinker A, Cho CY, Schultz PG & Jaenisch R. (2009) Reprogramming of Murine Fibroblasts to iPS Cells With Chemical Complementation of Klf4. PNAS. 106, 8912–8917. Abstract | PDF | Supporting Information | Times cited: 107

PNAS 50-most read articles, June 2009
Highlighted in Nature Cell Biology (2009). Chemical iPS Cocktails | Article | PDF
Highlighted in Nature Reports (2009). New Types of ES Cells Generated by Stabilizing Pluripotency | Article
Highlighted in Regenerative Medicine (2009) | Article | PDF
Highlighted in Assay and Drug Development Technologies (2009). Discovering Pluripotent Compounds | PDF

Zhu S, Wurdak H, Wang J, Lyssiotis CA, Peters EC, Cho CY, Wu X & Schultz PG. (2009) A Small Molecule Primes Embryonic Stem Cells for Differentiation by Targeting NME2. Cell Stem Cell 4, 416–426. Abstract | PDF | Supporting Information | Times cited: 39

Highlighted in Nature Chemical Biology (2009). Endowing Endoderm | Article | PDF
Highlighted in Cell Stem Cell (2009). Using Small Molecules to Great Effect in Stem Cell Differentiation | PDF
Highlighted in Molecular Interventions (2009). Stauprimide: A Small Molecule Directs Stem Cells to Differentiate | PDF

Blatt NB, Boitano AE, Lyssiotis CA, Opipari AW & Glick GD. (2008) Bz-423 Superoxide Signals Apoptosis via Selective Activation of JNK, Bak, and Bax. Free Radical Biology Med. 45, 1232–1242. Abstract | PDF

Lyssiotis CA, Walker J, Wu C, Kondo T, Schultz PG & Wu X. (2007) Inhibition of Histone Deacetylase Activity Induces Developmental Plasticity in Oligodendrocyte Precursor Cells. PNAS. 104, 14982–14987. Abstract | PDF | Supporting Information | Times cited: 38

Highlighted in Cell (2007). Leading Edge: Glial Precursors Break Their Commitment | PDF

Bednarski JJ, Lyssiotis CA, Roush RR, Boitano AE, Glick GD & Opipari AW. (2004) A Novel Benzodiazepine Increases the Sensitivity of B Cells to Receptor Stimulation with Synergistic Effects on Calcium Signaling and Apoptosis. J. Biol. Chem. 279, 29615–29621. Abstract | PDF

REVIEWS and COMMENTARIES

^†Lyssiotis CA, Lairson LL, Boitano AE, Wurdak H, Zhu S & ^†Schultz PG. (2011) Chemical Control of Stem Cell Fate and Developmental Potential. Angew. Chem. Int. Ed. 50, 200–242. Abstract | PDF | ^†corresponding author

^†Lyssiotis CA, Charette BD & Lairson LL. (2009) Reprogramming Developmental Potential. Lakshmipathy U, Chesnut JD & Thyagarajan B, eds. In: Emerging Technology Platforms for Stem Cells. New York, NY. John Wiley & Sons Press, Inc.; 51–85. Summary | PDF

^†Lyssiotis CA. (2007) Cautiously Interpret Data. Chemical & Engineering News, Nov-12, 6 | Article