CANCER METABOLISM | Cancer cells have different metabolic requirements than their normal counterparts. What do such differences mean and can we exploit them for therapeutic benefit? See link for an introduction to cancer metabolism and Costas' efforts as a member of the Cantley lab to understand how and why cancer cells differ metabolically from normal cells.

REPROGRAMMING | An individual's heart, brain and skin cells all possess the same genetic information yet appear and behave very differently. An understaning of how this occurs and a means to turn readily accesible cell types, like skin cells, into therapeutically desirable cell types, like heart cells, would have a profound impact on age-related and degenerative diseases. See link for an introduction to reprogramming and a summary of the insights gained by Costas and colleagues as a member of the Schultz lab.